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Hexamethyldisilazane (Hmds)

Hexamethyldisilazane is a trimethyl terminated silyl amine. It is an extremely strong silyl agent. It can be described as Bis(trimethylsilyl)amine and it's normally abbreviated as HMDS.
  • km-673

  • KMW

  • 999-97-3

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Product name: 1, 1, 1, 3, 3, 3-Hexamethyldisilazane

CAS No. 999-97-3


Appearance:    Colorless transparent liquid

Assay: 99%min


Applications:

It can be used to introduce trimethylsilyl group into organic molecules containing an active hydrogen atom such as alcohols, carboxylic acids, amines etc. The most common industrial application is in production of semi synthetic beta lactum antibiotics as ampicillin and cephalexin.

The usual procedure is to protect the carboxylic group in the antibiotic with HDMS followed by acylation with the desired acylchloride. Finally, desilylation under mild aqueous conditions gives the desired product.

Package: 150kg/ iron drum.


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